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Evidence-based medicine is not a cure-all

08 Mar 2010

Dr Michael Dixon, medical director at the Prince's Foundation for Integrated Health and a GP in Cullompton, Devon, hits back at homeopathy's critics

It does get tedious. Invective after diatribe after vilification. If it's not me they are attacking then it is anyone else who dares to disagree with their diktats.

Now Professor Edzard Ernst – a leading member of science's militant tendency – insists on bombarding myself and like-minded colleagues in Pulse, our own journal.

This in a week when the BMJ published an obituary on a GP friend, Dr Kieran Sweeney, with whom I wrote two books and who knew more than most about the benefits of integrated medicine. It says: 'He saw the folly of valuing scientific evidence above all else, when hard evidence so often turned to thin ice in his consulting room.'

The new fundamentalists rarely, if ever, think about the patient. That is not surprising. Most are not doctors. Even Professor Ernst hasn't faced a real live patient for at least seventeen years. Those were the days when you could still, just, get away with 'doctor knows best'. Seems he is still living that dream.

For us who are GPs, healing is our job. We try to make some sense of the complexity of our patients' problems and offer them hope. What, I wonder, would Professor Ernst and the rest of his coterie say to the patient who comes to us in pain and distress from their fibromyalgia or chronic tiredness or frequent infections? Or the other hundred and one conditions where science has no effective answer?

They seem not to have grasped the central fact about long-term conditions. They are long-term precisely because there is no treatment – EBM or otherwise – that will cure them. All we as doctors can do is alleviate symptoms and possibly, just possibly, delay the progression of the disease. On the patient's terms if at all possible.

Evidence based medicine is not the cure-all it is made out to be. I wish it were, but if ever there were snake-oil salesmen, it is those who claim it is.

As for Professor Ernst's complaints about my comments to the Sunday Telegraph, Pulse's readers understood I said that even those who believe homeopathy provides nothing but placebo must surely accept that it sometimes helps those for whom conventional medicine has no answer.

I do not know whether the effects of homeopathy are purely placebo or whether the substance of the medicine has a biological action. In fact, I don't use homeopathy myself. I have never had the time to train in it. But I do know two things about it.

First, homeopathic doctors are neither gullible idiots nor liars. They treat their patients with compassion and professionalism, and often achieve worthwhile results.

Secondly, it is not true that science has proved homeopathy is nothing more than placebo. There is a small number of good quality, RTC trials of homeopathy – including at least one looking at fibromyalgia – that appear to demonstrate a small but significant effect greater than placebo. Data exists that indicates the effects of homeopathy may be real. For instance, in this month's International Journal of Oncology, the lead scientist from one of the most reputable cancer centres in the world has confirmed the ability of four homeopathic remedies to bring about programmed cell death in breast cancer cell lines in the laboratory.

Data is data, whether it is convenient or not. It is hardly good science to pretend it doesn't exist.

If a GP, whether a homeopath or not, tells a patient in good faith that he or she will get better, then what is the problem? If the patient gets better – even if faith, placebo or the human effect is the catalysing factor – the point is that the patient gets better. If the patient gets better simply because of suggestion (the therapeutic interaction) rather than the specific treatment, all that matters is that the patient gets better.

Professor Ernst is not interested in whether the patient gets better. He wants doctors to serve science first and our patients last, inhabiting a grey and nihilistic desert that denies the role of the doctor as healer and condemns us to being slaves of population-based statistical totalitarianism.

If I were a patient with an incurable disease, I would go for compassion over cold over-interpretation of evidence every time. But in fact, I also believe that many of the treatments that Professor Ernst seeks to rubbish do appear to work for my patients.

There is data to suggest homeopathic treatment benefits patients, argues Dr Dixon

READERS' COMMENTS

Anonymous,
08 Mar 2010
Fine words. But meaningless. As a patient, I would very much like it if my doctors did not mislead me. Supporters of quackery continuously mislead. Take the report here of homeopathy killing cancer cells in a test tube. The study showed 87% extra neutral alcohol killed cancer cells (no surprise). The study failed to undertake any analysis that would show how homeopathic alcohol behaved differently from non-magic alcohol. It is typical of the literature on homeopathy - badly designed, under-powered and over-extrapolated. Dr Dixon should know better than using such studies to promote his favourite magic. Andy Lewis
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Anonymous,
08 Mar 2010
No one said it was but it does have one thing going for it. The clue is in the name 'evidence'. Andy Baker
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Anonymous,
08 Mar 2010
'If I were a patient with an incurable disease, I would go for compassion over cold over-interpretation of evidence every time.'
<p>
This is a classic false dichotomy (plus an egregious hyperbole in 'over-interpretation', which I shall ignore).
<p>
Dr Dixon provides no reason to think that a GP facing a patient with an incurable disease would have only two options of compassion or evidence-based treatment. If he were to look at the GP curriculum, he would see that GPs are expected to provide both compassion, AND the best available treatment, where what is 'best' is determined by a critical appraisal of the evidence.
<p>
It is a mistake in logic and ethics to think that compassion can justify ineffective or harmful treatment, especially if the treatment is given under false pretences - false pretences of either the effectiveness of the treatment, or the diligence of the professional in assessing the worth of the treatment. Michael Power
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Anonymous,
09 Mar 2010
Bravo to Dr. Michael Dixon for his forthright comments regarding homeopathy.
<p>
Something the CAM denialist scientism-ists seem to forget is that it is all about the patient.
<p>
The argument against homeopathy by utilizing the 'placebo' effect explanation has one grave error. It admits the homeopathic curative effect but then tries hastily to explain one unknown, the mechanism of homeopathy, by quickly substituting another unknown - the placebo effect also of unknown mechanism.
<p>
With hand-waving distractions reminiscent of a magican, the scientism-ists shout at us - pay no attention to homeopathy, look over here, over HERE please and allow us to explain.
<h>
But that is not an explanation - it is only a misdirection. For whose benefit and to what end is left as an exercise for the reader. James Pannozzi
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Anonymous,
09 Mar 2010
Dr Dixon has dealt a pretty full house of misunderstandings here. Firstly, there is the old canard that EBM has forgotten about patients. Has Dixon forgotten what clinical trials are? They are studies of patients - yes, real live people with diseases. I am currently running trials in palliative care, and can't suppress a tear when I read the records of someone dying of cancer. Yet the trials show us that their last days are made far more tolerable and fulfilling by the treatment we are testing. This is the compassion in science.


Dixon displays his shallow understanding of EBM by referring to "a small number of good quality, RTC (sic) trials of homeopathy". The whole point is that some 200 trials are in the literature, and GCSE statistics is all that is required to explain how some of them come out positively. The same applies to one-off in vitro studies.


Indeed Dixon does not appear to understand what science is. It is not in the business of disproving homeopathy or anything else. It is the business of `crash testing ideas' (to quote Richard Feynmann). The homeopaths make some bizarre claims, which are testable by science. That has been done, and the evidence is lacking. Trying to prove a negative is not the point.


Publishing defamatory assumptions about the state of mind of a previous author is not worthy of any profession, let alone medicine. Only Professor Ernst knows for sure what interests him. I would only guess that he is interested in the truth, something which Dixon might like to remember next time he is obtaining informed consent from a patient. Les Rose
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Anonymous,
09 Mar 2010
No-one, so far as I know, has said that evidence-based medicine is a cure-all. It's just a million times better than non-evidenced medicine. Homeopathy may have something to offer the worried well, most of whom wouild fare better if they understood minor illness well enough to self-treat and leave their doctor in peace.
I am a medical journalist, writing obituaries of doctors and scientists for two medical journals and a national newspaper. The people I write about have done marvellous things in their lives. My most recent published obit, in the Lancet of 6 March, was of the immunologist Eli Sercarz; he unravelled the mechanisms of autoimmunity. Can anyone name a homeopath who has saved lives or advanced our understanding of disease? I can't, but can think of a few who wear expensive suits and hold the hands of rich people with very minor ailments.
In 2003 I was cured of a poor-prognosis high grade lymphoma with high-dose chemotherapy and a stem cell transplant. I think a homeopath in my situation would also opt for the evidence-based treatment. Caroline Richmond
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Anonymous,
09 Mar 2010
Dixon tries to hide the flaws in his arguments behind aggression. I know of chiropractors who have sued for less than Dixon's insults. I will not do anything like that but am worried that Dixon's outburst backfires and tarnishes the reputation of the organisations that employ him. When you are in a hole, Michael, it would be wise to stop digging! Edzard Ernst
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Anonymous,
09 Mar 2010
There is a saying "science (and that includes evidence-based medicine) gives us the freedom to doubt" and if a clinical trial does show a positive result it should be replicated to see if it is a false positive. As homeopathy is based on pseudo-scientific nonsense, (which would require every physics and physiology book to be rewritten), when the clinical trials are replicated they will undoubtedly fail. History will show I am right so let's just test it again and wait and see..
Attacking Prof Ernst is shooting the messenger. Prof Ernst has never, and will never, rubbish any therapy. He just tells it like it is based on evidence-based medicine and thank goodness for progress, he does. We in Australia certainly appreciate his bottom line opinion which is based on extensive research. I understand that Prof Ernst worked in a homeopathic hospital, so he understands more than most of us the risks and benefits of this placebo therapy.
I seem to remember that even Prof Ernst can appear to have 'changed his mind'. At one point Saw Palmetto worked and now it doesn't does that mean he 'changed his mind' of course not! It means that more and better quality trials have been conducted and the results have changed as I said he tells it like it is.
Loretta Marron
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Anonymous,
09 Mar 2010
Kudos Dr Dixon.

I agree with most of what you have said. At the end of the day it is important that patient feels better, whichever way he does. Most of us have forgotten this under NICE guidelines and QOF targets and various ways to reduce BP and risk factors whether the patient is happy with the treatment or not

bhuvnesh nindrajog
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Anonymous,
09 Mar 2010
What an emotive rant.

That doctors should choose to tell patients the truth doesn't mean they lack compassion.

Most of the "new fundamentalists" may not be doctors but we are all, at some time in our lives, patients and we prefer not to be patronised and lied to, thanks all the same.
Maria MacLachlan
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Anonymous,
09 Mar 2010
Michael Dixon's idea of holism seems to be that if you have chronic fatigue, fibromyalgia or the like that there must be some pill to give the patient, and if orthodox medicine can't do it, then homeopathy can help. However, no amount of goodwill makes a treatment work. Most holistic GPs know when medicines are not appropriate and give financial or relationship or behavioural advice - this is what holistic medicine has always been about - but it is the alternativists who insist that they have a 'pill for every ill'. That is not holism, it is mumbo-jumbo, an important distinction. james may
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Anonymous,
09 Mar 2010
It is, perhaps, a sign of the level of argument used by CAM advocates that Dixon describes Ernst as "leading member of science's militant tendency", for no better reason than that Ernst is scrupulous about assessment of evidence, and that the evidence so often comes out unfavourable for CAM. It is the latter that is the problem for Dixon, and shooting the messenger doesn't help..

There is, though, one very interesting aspect to Dixon's post. He says "I do not know whether the effects of homeopathy are purely placebo or whether the substance of the medicine has a biological action". That is an admission that most certainly not be made by homeopaths. Even the 'responsible wing' of homeopaths, typified by Peter Fisher, continue to insist that it is not placebo.

Now that Dixon has admitted that homeopathy may be a placebo, would it not have been more proper to go on to explore the ethical consequences of pretending that it is not? It is the very essence of old fashioned paternalistic medicine to pretend that it's a good idea to deceive the patient for the sake of eliciting a placebo reaction.

One problem with encouraging belief in magic medicine is that most of its practitioners are not as knowledgeable or responsible as Peter Fisher, or, I dare say, Michael Dixon. Fisher says he was "very angry" when homeopaths were caught recommending their sugar pills for the prevention of malaria. But it doesn't take long to find that the vast majority of (non-medical) homeopaths remain quite happy to pretend they can cure malaria, cholera, AIDS and almost anything else under the sun. This is the point at which ignoring evidence becomes a danger to patient safety.

I somehow doubt that Dr Dixon would prescribe a sugar pill for cholera, but it would be helpful if he would condemn those that do, rather than encouraging them.

Incidentally, the study he cites in the International Journal of Oncology appears not to have been conducted blind. When one recalls that the infamous Benveniste study failed when repeated with blinding, it is odd that this paper was ever accepted for publication. I'm afraid that Dixon is clutching at straws.


David Colquhoun
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Anonymous,
09 Mar 2010
What arrogance! To suppose that when patients get better it's because of what the doctor does. Sometimes patients just get better. The whole point of evidence-based medicine (a redundancy there! If the evidence doesn't show that something works, it's not really medicine!) is so that we don't fool ourselves the way our well-intended ancestors did.

Here is the real question: would we go on using penicillin if we had the kind of evidence supporting its effectiveness that we have for homeopathy? OF COURSE NOT! John Eubanks
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Anonymous,
09 Mar 2010
Dr Dixon may wish to read the December edition of the American Journal of Bioethics which is devoted entirely to robust consideration of the ethics of knowingly prescribing placebo treatments. In particular Miller and Colloca's article about the evidence for and against using placebos outside of research.
Am J Bioeth. 2009 Dec;9(12):39-47.

At least if some readers acquaint themselves with current thinking about the issue, some good may come of this embarrassing diatribe. Mick Vagg
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Anonymous,
10 Mar 2010
The quasi-science of Homeopathy cannot replace good evidence-based medicine. Homeopathy is therefore not a substitute for EBM, it is a substitute for patient-centred clinical method. The failure to engage in PCCM by some GPs is what has given homeopathy credibility. Bryan Moore
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Anonymous,
10 Mar 2010
Goodness how we hate to have our concepts questioned- Using EBM alongside CAM in NHS primary care I am cognisant of those patients who do not fit inclusion criteria of RCT's, of the fact 13% of medical interventions have an evidence base meaning statistically I am advocating placebo in 87% of my interventions alongside my clinical colleagues, of gut instinct in when to refer a seemingly 'not that ill' child and applying in good faith what is best for the patient who is in the consulting room. The fact EBM, placebo and CAM advice can be considered, accepted, discarded or discussed by the patient puts the patient in the centre ground. Sociological data showed 50% of prescriptions do not make it to the chemist and of those that do 50% are consumed correctly. Sociological 'Clinical Iceberg' data describes 2 people for eveyone who presents to the Health Service have the same condition and choose a different route to manage their symptoms. The arrogance of non- clinical and non GMC regulated commentators to this posting is astounding. Fortunately patient interests, choices, integrity and intelligence are being defended and in the spirit of democracy will continue to be free from the reductionist harm espoused by these well intentioned but misguided myopes. What a shame waring tribes continue schism whilst clinical organisations like the RCGP teach us NLP- another well-researched RCT proven intervention utilising many of the attributes of CAM? Andrew Sikorski
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Anonymous,
10 Mar 2010
Goodness how we hate to have our concepts questioned- Using EBM alongside CAM in NHS primary care I am cognisant of those patients who do not fit inclusion criteria of RCT's, of the fact 13% of medical interventions have an evidence base meaning statistically I am advocating placebo in 87% of my interventions alongside my clinical colleagues, of gut instinct in when to refer a seemingly 'not that ill' child and applying in good faith what is best for the patient who is in the consulting room. The fact EBM, placebo and CAM advice can be considered, accepted, discarded or discussed by the patient puts the patient in the centre ground. Sociological data showed 50% of prescriptions do not make it to the chemist and of those that do 50% are consumed correctly. Sociological 'Clinical Iceberg' data describes 2 people for eveyone who presents to the Health Service have the same condition and choose a different route to manage their symptoms. The arrogance of non- clinical and non GMC regulated commentators to this posting is astounding. Fortunately patient interests, choices, integrity and intelligence are being defended and in the spirit of democracy will continue to be free from the reductionist harm espoused by these well intentioned but misguided myopes. What a shame waring tribes continue schism whilst clinical organisations like the RCGP teach us NLP- another well-researched RCT proven intervention utilising many of the attributes of CAM? Andrew Sikorski
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Anonymous,
10 Mar 2010
Pragmatic trials or 'comparative effectiveness research' is something that's targeted to providing answers for issues that relate to health service research rather than questions about whether a particular therapy works better than placebo. The Americans have recently come to the conclusion that placebo controlled trials frequently offer very little practical help to clinicians in practice as the questions they really want answered to relate to whether treatment A works better than treatment B or more frequently whether treatment is more cost-effective than treatment B. As a consequence they have made new funds available with over $1Billion set aside for comparative effectiveness research which seems to be exactly what Ernst is dismissing. These questions are not often answered by placebo controlled randomised trials but are usually addressed by a more pragmatic approach that may not involve a placebo arm.

To take Ernst's example about homeopathy. In reality homeopathic consultations usually last for about half an hour within the NHS (not 3 hours). If the consultation is powerful enough to help patients with their fibromyalgia in a safe and cost-effective manner, particularly when we have no evidence-based conventional treatment to offer them, then it would appear to be a reasonable clinical decision. Almost two thirds of patients with fibromyalgia are unable to work and conventional approaches tend to be non-evidence based, non-standardised and clinically ineffective. Recently two systematic reviews have been published looking at CAM interventions for fibromyalgia: one involved 4 clinical trials of homeopathy. The trials were of variable quality but all showed a positive outcome for homeopathic medicine over placebo. Similarly with trials involving acupuncture, they generally indicate that fibromyalgia can be helped by this intervention.

It may well be that the effect of homeopathy lies in the very unique nature of the consultation which could be looked upon as amplifying a positive therapeutic relationship with the added elements of cognitive behavioural therapy and motivational interviewing. It would be interesting to debate whether this is genuinely “placebo” simply because it doesn’t involve the prescription of a pharmaceutical agent. Would that line of reasoning mean that all techniques that involve “talking therapy” such as CBT are simply placebo? Should we also consider exercise a placebo because it doesn’t involve a pharmaceutical agent?

Ernst raises some interesting issues but serve to over-simplify clinical decision-making and the definition of placebo in the service of his interpretation of evidence-based medicine.


George Lewith
10 March 2010
Professor George Lewith
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Anonymous,
10 Mar 2010
Andrew Sikorski - where did the 13% figure come from? There is no doubt that a lot of CAM 'medical interventions' don't have an evidence base. This would of course distort the data. Really a medical intervention should be defined as one that does have an evidence base. The question really is what do patients actually get treated with? Sackett et al in 2000 presented GP data that 81% of interventions used in practice are evidence based. Clearly some GPs (myself included) choose to use interventions based on their evidence. Is it possible that some don't?? James May
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Anonymous,
11 Mar 2010
Three different results of dangers of evidence-based medication hit my in-box from various sources this month from negatives on HRT, diabetes medication, misleading pharmaceutical studies etc.. It seems that 'evidence based' is a phrase coined to exclude anything that can not be patented to make money on a large scale for a large corporation or businesses. And of course funding is not thrown at producing efficacy results that lead to the downfall of 'evidence based' results.

The facts are that people are fed up with the current system of prescribing drugs that lead to side effects that require further drugs and so on.

I am 67 years of age and have found other solutions to be at this age so that I can tell you that at this age I am on no medication other than fish-oil, Seatone and Glucosamine Choindrine for my aging limbs - and part of the reason for that was an accident where I tore my ligaments.

My mother ended up in a Psychiatic hospital with a total nervous break down - the major cause I would say was 30 years of valium taking and never dealing with the feelings and emotions from her childhood and war experiences. If I had known then what I know now, this could have possibly been avoided. But then, we relied on the 'evidence based' propoganda that valium was safe for long-term use. Bruni Brewin
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