This site is intended for health professionals only

At the heart of general practice since 1960

Benefits of antidepressants limited in children

Antidepressants show only limited activity in children and adolescents although the benefit may increase with age and be greater with fluoxetine, a meta-analysis show

A team of UK and US researchers analysed data from 30 studies involving 3,069 participants. The pooled response rate was 22% higher than placebo, with an overall response rate of 10.9%.

There was some indication that adolescents were more likely to respond than younger children, with a number needed to treat of eight compared with 21.

Br J Psychiatry 2008;193:10-17

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say