Benefits of antidepressants limited in children
Antidepressants show only limited activity in children and adolescents although the benefit may increase with age and be greater with fluoxetine, a meta-analysis show
A team of UK and US researchers analysed data from 30 studies involving 3,069 participants. The pooled response rate was 22% higher than placebo, with an overall response rate of 10.9%.
There was some indication that adolescents were more likely to respond than younger children, with a number needed to treat of eight compared with 21.
Br J Psychiatry 2008;193:10-17