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CBT boosts quit rates

Cognitive behavioural therapy can sharply improve quit rates among smokers with a psychotic disorder, an Australian study concludes.

Researchers compared CBT and nicotine replacement therapy with routine care alone in 298 regular smokers with a psychotic disorder. Patients received six hourly sessions with a therapist followed by two booster sessions.

The proportion of patients who quit at one year was 18.6 per cent among those in the CBT group, but only 6.6 per cent with routine care.

American Journal of Psychiatry 2006;163:1934-42

BNP test better in women

B-type natriuretic peptide testing predicts mortality in women much more effectively than in men, a Swiss study has shown.

The research team studied 190 women and 262 men presenting with acute dyspnoea, measuring BNP levels and then following them for two years.

Levels of BNP were similar in men and women, but were twice as high in women who died as in men who died. BNP levels over 500pg/ml increased a woman's risk of death by 5.1-fold, but a man's by only 1.8-fold.

Journal of the American College of Cardiology

2006;48:1808-12

Nocturia a risk for CHD

Nocturia is an independent risk factor for coronary heart disease, an Israeli study concludes.

Researchers examined the relationship between nocturia and CHD risk in 456 subjects born in 1920 or 1921 who were examined in 1990 and followed up

until 2002.

Average 12-year survival was 61 per cent in those with nocturia but 72 per cent in those without.

The American Journal of Cardiology 2006;10:1311-5

Two drugs in urinary cases

Combination treatment appears to be more effective than single drug therapy for men with urinary tract symptoms.

The researchers conducted a placebo-controlled trial in men with symptoms such as hesitancy and intermittency at 95 urology clinics in the US. They tested the effectiveness of tolterodine extended release and tamsulosin, alone or in combination.

Some 80 per cent of patients receiving both drugs reported treatment benefit by week 12, compared with 65 per cent on tolterodine ER and 71 per cent of those on tamsulosin.

JAMA 2006;296:2329-35

Advice delays diabetes

Intensive lifestyle interventions can have long-term benefits for reducing diabetes incidence, Finnish researchers conclude.

They conducted a randomised trial in 172 men and 350 women with impaired glucose tolerance. Patients received an intensive, individual lifestyle intervention or, for controls, just general lifestyle advice.

The incidence of diabetes was 4.3 per 100 person-years in the intervention group, significantly lower than the 7.4 per 100 person-years in controls.

The Lancet 2006;368:1673-9

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