CHD patients should take statins at night
GPs should advise patients to take statins at night following research that shows their
cholesterol-lowering effect is impaired when taken in the morning.
Study co-author Professor Greg Rubin, professor of general practice at the University of Sunderland and a GP in the city, randomised 60 patients taking statins at night for the prevention of coronary heart disease to morning or evening dosing for eight weeks.
Preliminary results for 26 patients showed levels of chol-esterol and triglycerides in the morning group increased significantly over the course of the study compared with patients in the night group.
The study, presented last week at the annual meeting of the Northern Primary Care Research Network in Durham, said statin manufacturers recommended nocturnal dosing but compliance might be compromised because many patients were also taking other cardioprotective drugs.