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CKD risk double in women

Women are almost twice as likely to have chronic kidney disease as men, according to a new analysis.

The study of 130,000 adults from England found prevalence of stages 3 to 5 CKD was as much as 1.8 times higher in women.Researchers also found the overall prevalence of stages 3 to 5 CKD was higher than many studies had suggested, estimating a figure of at least 8.5 per cent. This was 'inevitably' an underestimate, the researchers said, as they had to assume there were no untested people in primary care.Study leader Dr Paul Stevens, consultant in nephrology at Kent and Canterbury Hospital, said: 'These data clearly show an exponential increase in prevalence of stage 3 to 5 CKD with age and suggest female gender is a predictor of lower levels of eGFR.'He added: 'The age-standardised prevalence of stage 3 to 5 CKD was 10.6 per cent for females and 5.8 per cent for males.'Although comparisons with other studies need to be viewed with caution because of differences in methodology, the gender-specific rate for CKD stage 3 to 5 in this study compares with results from a population study in Iceland showing age-standardised rates of 11.6 and 4.7 per cent for females and males, respectively.'Patients with CKD were at a 2.1-fold raised risk of hypertension, a 1.7-fold raised risk of cardiovascular disease and a 1.3-fold raised risk of diabetes.The study, published online by Kidney International, involved calculating eGFRs for the 30 per cent of patients in the cohort who had valid creatinine values recorded.

• Managing CKD – Clinical, page 38

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