Cookie policy notice

By continuing to use this site you agree to our cookies policy below:
Since 26 May 2011, the law now states that cookies on websites can ony be used with your specific consent. Cookies allow us to ensure that you enjoy the best browsing experience.

This site is intended for health professionals only

At the heart of general practice since 1960

Kidney stones ‘increase coronary risk’ in women

A history of kidney stones is linked with an increased risk of coronary heart disease (CHD) in women but not in men, claims a new study.

The study

Researchers looked at the link between kidney stones and risk of incident coronary heart disease in 242,105 participants from three cohorts without a history of  CHD. All participants were asked whether they have a history of kidney stones and were followed up every two years. CHD, defined as a composite of non-fatal or fatal myocardial infarction (MI), fatal CHD, or coronary revascularization procedure was the primary outcome.

The findings

There were 19,678 patients with a history of kidney stones and a total of 19,678 incident cases of CHD after follow up. Women with a history of kidney stones had a 30% increased risk of CHD and a 26% increased risk of fatal and non-fatal myocardial infarction, compared with those without such as history.  No significant risk of CHD was established for men with a history of kidney stones, compared with those who have not.

What this means for GPs

The researchers concluded: ‘Further research is needed to determine whether the association is sex-specific and to establish the pathophysiological basis of this association.’

JAMA 2013; 310: 408-415

Have your say