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At the heart of general practice since 1960

The newborn digestive system undergoes many changes in the first few months of life. In order to support an infant’s nutrition, physiology and natural immunity, it must1,2:

  • Acquire a microbiota that consists of billions of beneficial bacteria
  • Develop the right levels of digestive enzymes
  • Form a fully functioning gastrointestinal barrier
  • Create a complex communication network with the rest of the body

With such a dynamic environment, it is hardly surprising that functional gastrointestinal disorders (FGIDs) are common in infancy3,4.


  1. Bourlioux P et al. The intestine and its microflora are partners for the protection of the host. Am J Clin Nutr 2003; 78: 675-683.
  2. O’Toole PW & Conney JC. Probiotic bacteria influence the composition and function of the intestinal microbiota. Interdiscip Perfect Infect Dis 2008; 1-9.
  3. Iacono G et al. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005; 37(6): 432-438.
  4. Vandenplas Y et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015; 61(5):531-537.
  5. Hyman PE et al. Childhood functional gastrointestinal disorders. Neonate/toddler. Gastroenterol 2006; 130: 1519-1526.
  6. Van Tilburg MA et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. J Pediatr 2015; 166: 684-689.
  7. Vandenplas Y et al. Gut health in early life: implications and management of gastrointestinal disorders. 2015. Essential Knowledge Briefing. Wiley, Chichester (2015).


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