Cookie policy notice

By continuing to use this site you agree to our cookies policy below:
Since 26 May 2011, the law now states that cookies on websites can ony be used with your specific consent. Cookies allow us to ensure that you enjoy the best browsing experience.

This site is intended for health professionals only

At the heart of general practice since 1960

About gammaCore

Treat migraine and cluster headache at the core

  • gammaCore: Novel, non-invasive vagus nerve stimulation (nVNS) delivered by a patient friendly,
    hand-held device.
  • Completely non-invasive therapy stimulates the cervical branch of the vagus nerve. No surgery.
    No invasive procedure.
  • VNS demonstrates the ability to suppress high glutamate levels in the trigeminal nucleaus caudalis
    (TNC), which may be the pain-blocking mechanism of nVNS1

The next frontier of headache pain management

  • One of the largest clinical programs in headache: 3 randomized clinical trials completed, 3 additional
    studies in progress.
  • Non-pharmacologic, flexible treatment option with a role in both acute and preventative treatment
  • Side effects are primarily local, mild, and transient

gammaCore: bringing the clinical potential of nVNS to life

  • gammaCore makes nVNS practical, safe, and flexible
  • Avoids the surgery-related adverse effects and costs of implantable neuromodulating devices and potentially limits adverse effects related to continuous on-off stimulation2,3
  • gammaCore is administered with a hand-held device, about the size of a mobile phone that generates a unique electrical signal. A conductive gel is applied on the stimulation surfaces of the device and it is placed on the neck. Each dose takes approximately 2 minutes to administer (you may require more than one dose per treatment).


1. Oshinsky ML, Murphy AL, Hekierski H Jr., Cooper M, Simon BJ. Non-invasive vagus nerve stimulation as treatment for trigeminal allodynia. Pain (2014), doi:
2. Goadsby PJ, Grosberg BM, Mauskop, Cady R, Simmons KA. Effect of noninvasive vagus nerve stimulation on acute migraine: an open-label pilot study [published online March 7, 2014]. Cephalalgia. doi:10.1177/0333102414524494.
3. Jürgens TP, Leone M. Pearls and pitfalls: neurostimulation in headache. Cephalalgia. 2013;33(8):512-525