Treat migraine and cluster headache at the core
gammaCore: Novel, non-invasive vagus nerve stimulation (nVNS) delivered by a patient friendly,
Completely non-invasive therapy stimulates the cervical branch of the vagus nerve. No surgery.
No invasive procedure.
VNS demonstrates the ability to suppress high glutamate levels in the trigeminal nucleaus caudalis
(TNC), which may be the pain-blocking mechanism of nVNS1
The next frontier of headache pain management
One of the largest clinical programs in headache: 3 randomized clinical trials completed, 3 additional
studies in progress.
- Non-pharmacologic, flexible treatment option with a role in both acute and preventative treatment
- Side effects are primarily local, mild, and transient
gammaCore: bringing the clinical potential of nVNS to life
- gammaCore makes nVNS practical, safe, and flexible
- Avoids the surgery-related adverse effects and costs of implantable neuromodulating devices and potentially limits adverse effects related to continuous on-off stimulation2,3
- gammaCore is administered with a hand-held device, about the size of a mobile phone that generates a unique electrical signal. A conductive gel is applied on the stimulation surfaces of the device and it is placed on the neck. Each dose takes approximately 2 minutes to administer (you may require more than one dose per treatment).
1. Oshinsky ML, Murphy AL, Hekierski H Jr., Cooper M, Simon BJ. Non-invasive vagus nerve stimulation as treatment for trigeminal allodynia. Pain (2014), doi: http://dx.doi.org/10.1016/j.pain.2014.02.009.
2. Goadsby PJ, Grosberg BM, Mauskop, Cady R, Simmons KA. Effect of noninvasive vagus nerve stimulation on acute migraine: an open-label pilot study [published online March 7, 2014]. Cephalalgia. doi:10.1177/0333102414524494.
3. Jürgens TP, Leone M. Pearls and pitfalls: neurostimulation in headache. Cephalalgia. 2013;33(8):512-525