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Clopidogrel before angioplasty improves outcomes

Patients who receive clopidogrel before undergoing percutaneous coronary intervention (PCI) have better clinical outcomes, a systematic review suggests.

Data from 26 trials showed patients given a loading dose of clopidogrel before pre-PCI coronary angiography had an initial patency of 34.3%, significantly higher than the 25.8% in patients who did not receive the drug.

Pre-treatment with clopidogrel was also an independent predictor of early reperfusion and lowered the risk of death and reinfarction.

Circulation 2008 early online publication

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