Combination therapy better for hypertension
Adding another blood pressure drug is more effective than doubling the dose of monotherapy, concludes a US meta-analysis.
The study looked at 42 trials with 10,968 participants and compared the effect of doubling the dose of one antihypertensive, with the additive effects of combining drugs from two different classes.
They found the average blood pressure reduction in patients treated with a two-drug combination was approximately five times greater than doubling the dose of a single drug.
Am J Med 2009; 122: 290-300