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Combining hypertensives cuts renal event risk in type 2 diabetes patients

Prescribing combined antihypertensives significantly reduces the risk of adverse renal events in patients with type 2 diabetes, irrespective of their baseline blood pressure levels.

Australian researchers randomly assigned 11,410 patients to either a combination of perindopril 2mg and indapamide 0.625 mg a day or placebo, with doses doubled after three months.

After an average of 4.3 years of follow up, patients treated with antihypertensives had a significant 21% reduction in the risk of adverse renal events. The effect was consistent even in patients with an initial blood pressure of less than 120/70mmHg.

Journal of the American Society of Nephrology 2009; 19 February early online publication

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