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Depression treatment works eventually in adolescents

Adolescents with depression often respond eventually to maintenance treatment even if they appear initially to show no sustained improvement, a US trial reports.

Researchers analysed data from 439 patients aged 12 to 17 years from the Treatment for Adolescents with Depression Study, which has previously shown the benefits of combining fluoxetine with CBT.

Just under 40% of patients did not have a sustained response to the acute phase of treatment.

But the majority of these patients went on to respond to continuation or maintenance treatment – 80% of those on fluoxetine and CBT, 61.5% of those on fluoxetine alone and 77% of those on CBT alone.

Arch Gen Psychiatry 2008;65:447-55

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