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Drugs and lifestyle advice slow path to diabetes

Drug and lifestyle interventions can significantly slow the progression to diabetes for patients who are insulin-resistant, a new systematic review concludes.

The research provides further evidence to support a change in emphasis for GP

management of diabetes, from treating the disease to also

preventing it.

An analysis of 13 trials found that lifestyle interventions increased the chance of delaying or preventing diabetes by 50

per cent.

Use of oral hypoglycaemic agents reduced the chance of progression to diabetes by 44 per cent and anti-obesity agents by 66 per cent compared with placebo.

Study leader Dr Kamlesh Khunti, a GP in Leicester and clinical senior lecturer at the University of Leicester, said: 'Due to the diversity of the

interventions, three separate meta-analyses were undertaken. All showed a statistically

significant benefit of intervention to delay or prevent type 2 diabetes.

'Both lifestyle and pharmacological interventions significantly reduce the rate of progression to type 2 diabetes in individuals with impaired glucose tolerance.'

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