Family history of rheumatoid arthritis raises risk of joint damage
Colombian researchers have shown that a family history of rheumatoid arthritis is associated with the early appearance of joint damage.
A genetic analysis of 157 patients with rheumatoid arthritis found that after adjusting for confounders, the likelihood of substantial joint damage in a patient positive for a gene called anti-CCP3 was 99% higher than in patients who did not have the gene.
The researchers said their results emphasises the usefulness of assessing familial disease where a genetic service is available.
Journal of Autoimmunity 2009;32:64-69