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Fewer metformin deaths

Metformin may be associated with a lower risk of death from cardiovascular disease, than other oral diabetic medicines, a US meta-analysis suggests.

than other oral diabetic medicines, a US meta-analysis suggests.

Analysis of 40 studies showed treatment with metformin was associated with a decreased risk of cardiovascular mortality (pooled OR, 0.74; 95% CI, 0.62-0.89) compared with any other oral diabetes agent or placebo.

The results for cardiovascular morbidity and all-cause mortality were similar but not statistically significant and no other significant associations of oral diabetes agents with fatal or nonfatal cardiovascular disease or all-cause mortality were observed.

Archives of Internal Medicine 2008; 168: 2070-80

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