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Four drug regime best for H pylori

Using a four-drug regime eradicates Helicobacter pylori in more patients who complete the course than triple therapy, but compliance is lower.

In a study of 1,000 patients, the one-week quadruple regimen - lansoprazole, metronidazole, bismuth and tetracycline - eradicated the infection in 97% of those who completed the course, compared with 92% of those on triple therapy.

But compliance was only 86% with quadruple therapy, compared with 100% for triple therapy.

World J Gastroenterol 2008;14:3855-60

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