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Framingham poor in people with family history of early death

Framingham is a poor predictor of cardiovascular risk for individuals with a family history of premature death, say US researchers.

The study in 89 younger men and women with a family history of premature cardiovascular disease showed that despite low Framingham scores, they still had high levels of subclinical coronary heart disease.

Over 70% had low levels of HDL-cholesterol, 38% had high coronary calcium levels and nearly a quarter had high levels of C-reactive protein.

Clin Cardiol 2008; 31:542-45

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