This site is intended for health professionals only

At the heart of general practice since 1960

Fresh SSRIs pregnancy fears

A new study has sharpened

concerns over use of SSRIs in pregnancy after adding to the evidence that they raise the risk of malformations.

The Medicines and Healthcare Products Regulatory Agency said it would be examining the data as part of its ongoing review of SSRIs, which is expected to toughen up product warnings.

The study, published in November's Epidemiology, found

SSRI use in pregnancy increased risk of malformations by 34 per cent overall, and by 84 per cent when used in the second or third month. Preliminary results from the study were reported by Pulse last year.

Study leader Dr Pia Wogelius, a clinical epidem-

iologist at Aarhus University

Hospital in Denmark, said:

'We found an increased risk

of congenital malformations

after exposure to SSRIs in

early pregnancy.

'It is unclear whether the

effects were causal or due to

factors related to the underlying disease.'

The researchers carried out

a cohort study of 151,836 live

or still births in Denmark

between 1991 and 2003.

Of these, 0.7 per cent received at least one prescription for an SSRI between 30 days

before conception and the end of the first trimester.

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say