Fresh SSRIs pregnancy fears
A new study has sharpened
concerns over use of SSRIs in pregnancy after adding to the evidence that they raise the risk of malformations.
The Medicines and Healthcare Products Regulatory Agency said it would be examining the data as part of its ongoing review of SSRIs, which is expected to toughen up product warnings.
The study, published in November's Epidemiology, found
SSRI use in pregnancy increased risk of malformations by 34 per cent overall, and by 84 per cent when used in the second or third month. Preliminary results from the study were reported by Pulse last year.
Study leader Dr Pia Wogelius, a clinical epidem-
iologist at Aarhus University
Hospital in Denmark, said:
'We found an increased risk
of congenital malformations
after exposure to SSRIs in
'It is unclear whether the
effects were causal or due to
factors related to the underlying disease.'
The researchers carried out
a cohort study of 151,836 live
or still births in Denmark
between 1991 and 2003.
Of these, 0.7 per cent received at least one prescription for an SSRI between 30 days
before conception and the end of the first trimester.