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Galantamine safe for Alzheimer's

Galantamine is safe and may improve cognitive function in elderly patients with severe Alzheimer's disease, an early trial shows.

In the European study, led by UK researchers, 407 patients aged over 84 years living in nursing homes received galantamine titrated to 24 mg/day or placebo.

Scores on the severe impairment battery improved by 1.9 points in the galantamine group and fell by 3 points with placebo, but there was no significant improvement in overall activities of daily living. There was no difference in adverse events between the two groups or in ECG abnormalities.

The Lancet Neurology 2008 1 December early online publication

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