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Get real over ASCOT study

From Dr Dylan Kay, Nelson, Lancs

Regarding the NICE hypertension guidelines (News, 23 February), I have said it before and will say it again: ASCOT has been hyped.

To push calcium channel blockers ahead of thiazide diuretics suggests NICE et al have been reading different research to me.

ASCOT was flawed in structure, lacking appropriate control groups, and failed to take into account previous studies.

PROGRESS showed thiazides to be very effective but perindopril to be poor. ASCOT should have included a thiazide-plus-CCB wing.

Real science is about real comparison and ASCOT failed to do that.

NICE have cowed to self-interest and ignored scientific order and method.

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