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GP concern on BCG restriction

SSRIs reduce mortality from MI

Use of SSRIs in depressed patients following myocardial infarction appears to significantly decrease mortality.

US researchers analysed data from 1,834 patients with depression who took part in the Enhancing Recovery from Coronary Heart Disease study as a result of suffering an MI.

Among 301 patients who were treated with SSRIs, all-cause mortality was reduced by 41 per cent and the risk of recurrent MI by 47 per cent.

Archives of General Psychiatry 2005;62:711-712

Aminosalicylates may cut Ca risk

Aminosalicylates may reduce the risk of colorectal cancer, according to an analysis of the UK general practice research database.

Dutch researchers studied 18,969 patients who were taking aminosalicylates for irritable bowel syndrome. They performed a case-control analysis of 100 patients who subsequently developed colorectal cancer, 76 of whom had a history of ulcerative colitis. Regular users of aminosalicylates were 40 per cent less likely than irregular users to develop colorectal cancer.

Gut 2005; June 30 early online publication

Short-acting insulin no advantage

Short-acting insulins are no better for treating type 2 diabetes than regular insulin, according to Austrian researchers.

Their meta-analysis collated 42 randomised controlled trials comparing the effect of short-acting insulin analogues in 7,933 patients with type 1, 2 and gestational diabetes.

In patients with type 2 diabetes, short-acting insulins had no greater effect on HbA1c values or overall hypoglycaemia than standard insulins.

In type 1 diabetes, short-acting insulins had marginal benefits, reducing HbA1c values by a further 0.12 per cent.

Archives of Internal Medicine

2005;165:1337-1344

Low birthweight risk for depression

Babies with low birthweights are at increased risk of developing depression in later life, a UK study reports.

Researchers analysed data from 5,572 participants of the Aberdeen 'Children of the 1950s' study, examining their rates of psychological distress at the age of 45-51.

The risk of depression and anxiety was increased 49 per cent in babies born weighing less than 5.5lb. A one standard deviation decrease in birthweight at term increased risk by 4 per cent.

British Journal of Psychiatry 2005;187:21-28

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