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GPs increasingly cautious over SSRI use in children

NSAIDs 'don't raise the risk of MI'

Conventional NSAIDs do not increase the risk of myocardial infarction, researchers conclude.

The study contradicts Danish research which last week found all non-aspirin NSAIDs raised cardiovascular risk.

Swiss researchers analysed medication use in 8,688 patients with a first-time acute myocardial infarction and 33,923 controls, extracted from the UK general practice research database.

Risk of acute MI was not significantly increased in users of ibuprofen or naproxen. Diclofenac was associated with an increased risk of 23 per cent of marginal statistical significance.

Pharmacotherapy 2005;25: 503-510

Exercise cuts prostate cancer risk

Exercise appears to reduce the risk of prostate cancer in older men, a new study suggests.

US researchers analysed data on exercise habits and prostate cancer diagnoses from a prospective cohort study of 47,620 health professionals, followed up for 14 years.

In men aged 65 or older, regular, vigorous exercise reduced the risk of advanced prostate cancer by 67 per cent and of fatal prostate cancer by 74 per cent. The results were not explained by variable rates of PSA testing. No associations were observed in younger men.

Archives of Internal Medicine

2005;165:1005-1010

Vitamin E may ward off Parkinson's

Dietary vitamin E appears to reduce the risk of Parkinson's disease, a Canadian study reveals.

Researchers conducted a meta-analysis of eight studies conducted between 1966 and 2005, examining the role of vitamin E, vitamin C or beta carotene.

Moderate intake of vitamin E reduced the risk of developing Parkinson's disease by 19 per cent. High intake reduced risk by 22 per cent, although this fell short of statistical significance.

Lancet Neurology 2005;4:362-365

Early gluten exposure ups coeliac risk

Eating foods containing gluten in the first six months of life increases the risk of coeliac disease in predisposed children, US research shows. The prospective observational study examined 1,560 children at inherited risk of coeliac disease over 4.8 years.

Children exposed to gluten in the first three months were at double the risk of developing coeliac disease of non-exposed children, rising to a five-fold increased risk in children exposed from four to six months.

JAMA 2005;293:2343-2351

Difficult birth linked to autism

A difficult birth and a family history of mental illness may increase the risk of autism, a Danish study suggests. Researchers studied 698 children born with autism in Denmark after 1972, individually matching each case to 25 controls.

Risk of autism was increased by 63 per cent in children with breech births and by 55 per cent in those born before 35 weeks. Having parents with a history of psychiatric illness increased the risk of autism more than three-fold.

American Journal of Epidemiology 2005;161:916-925

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