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High-dose statins have major heart benefits in CKD patients

Intensive treatment with statins is particularly beneficial at reducing cardiovascular events in patients with chronic kidney disease, a subgroup analysis of the Treating to New Targets study shows.

US researchers examined data on 3,107 patients with mild to moderate CKD from the 10,000 on the TNT trial. Patients with CKD were older than those without, and had significantly higher triglyceride levels and greater baseline cardiovascular illness.

All patients in the TNT trial were randomly assigned to receive high- or low-dose statin therapy, given as atorvastatin 80 mg/day or 10 mg/day, respectively.

The risk of a major cardiovascular event fell by 32% with high-dose versus low-dose atorvastatin – a significantly greater reduction than the 15% fall in events in patients with normal kidney function.

J Am Coll Cardiol 2008;51:1448-54

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