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HRT increases GORD risk

Women who use postmenopausal hormone replacement therapy have a ‘modestly increased' likelihood of gastro-oesophageal reflux disease (GORD), according to an observational study.

The analysis of data from the US Nurses Health Study of over 100,000 women aged between 30 and 55 found 23% of women reported symptoms of GORD.

The risk of the condition was increased by 46% for past users and 66% for current users of hormone therapy compared with those who did not use it. The risk increased with dosage and duration of use, and approached that of non-users only after 10 years of stopping therapy.

Ann Intern Med 2008;168:1798-804

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