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I may just start prescribing Smarties now

So rimonabant has been withdrawn soon after becoming licensed.

I'm becoming increasingly pessimistic with regards to new drugs. This is not the first, or indeed the second or third, time this has happened.

The situation needs to improve regarding the satisfactory testing of new drugs if we as clinicians and our patients are to have confidence in new drugs and the drug industry as a whole.

I think I will start prescribing Smarties - at least I can enjoy taking them and know that the worst I am doing is adding to the patients' calorific intake.

Dr John Howard, Cottingham, Northamptonshire

Yet another new drug that promises a new life and means it too literally. The problem with lifestyle drugs is they have to have almost no side-effects for their development to be justified in the first place.

People need to take responsibility for their own life and weight - in most circumstances anyway. Perhaps it's irrational to expect the drug industry to be rational.

Dr Paul Joshi, Tamworth, Staffordshire

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