Increased MI risk in first month of taking oral steroids
Oral steroids appear to increase the risk of myocardial infarction, particularly in the first month of use, concludes a
large-scale study of UK general practice.
Researchers from the UK's Medicines and Healthcare Products Regulatory Agency and institutions in Spain found current use of oral steroids increased the risk of myocardial infarction by 42 per cent overall.
Over the first 30 days of oral steroid use there was an even more pronounced 2.2-fold increase in risk, according to the study of 404,183 people aged 50 to 84 identified through the UK general practice research database.
Study researcher Dr Luis Rod-riguez, director of the Centro Espanol de Investigaciun Farmacoepidemiolugica in Madrid, said: 'Any increase in risk, although small, would have a major public health impact among patients with CHD history.
'Therefore, caution should be exercised when prescribing oral steroids at high doses.'