This site is intended for health professionals only

At the heart of general practice since 1960

Insulin resistance predicts risk of ischaemic stroke

By Nigel Praities

Insulin resistance is independently associated with an increased risk of stroke and could be a new target for risk prevention, say US researchers.

They used the homeostasis model assessment (HOMA) – a widely used tool for measuring insulin sensitivity and secretion – on 1,500 adults without a history of diabetes or cardiovascular disease.

They found 23% of men and 26% of women were classified as insulin resistant - although the proportion varied according to ethnicity - highest in Hispanic and lowest in white people.

Insulin resistance significantly predicted the risk of ischaemic stroke, with a hazard ratio of 2.83. This effect was independent of sex, race/ethnicity, traditional vascular risk factors, metabolic syndrome and its components.

Lead author Professor Tatjana Rundek, professor of neurology at the University of Miami, said: This study provides evidence that insulin resistance as measured using HOMA is independently associated with an increased risk of first ischaemic stroke. Insulin resistance may be a novel therapeutic target for stroke prevention.'

Arch Neurol 2010; 67: 1195-1200

Diabetes risk

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say