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Leukotriene antagonists link to Churg Strauss Syndrome

Leukotriene antagonists appear to be associated with an increase in the risk of Churg Strauss Syndrome, UK researchers report.

Their systematic review analysed data from 40 studies, and identified 62 cases of newly developed Churg Strauss Syndrome after initiation of leukotriene antagonist therapy.

In 57 of these cases, patients developed the syndrome within 12 months of beginning treatment – and there were two cases of relapse after reintroduction of drug therapy.

The researchers said the limited available data suggested their could be a causal relationship.

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