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Missed bisphosphonate dose raises fracture risk

Elderly women who take less than 80% of their prescribed doses of alendronate or risedronate have a 27% increased risk of nonvertebral fractures, say Canadian researchers.

A case-control study of more than 30,000 women, set up to assess the implications of non-compliance, analysed non-vertebral fractures which occurred a year after starting therapy.

The risk was highest in women aged over 80. In these women, only taking eight in ten doses or less raised the risk of a nonvertebral fracture by 48%.

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