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Orlistat improves blood sugar control in type 2 diabetes

The 120mg dose of orlistat improves blood sugar control in patients with type 2 diabetes, even if patients do not successfully lose weight.

A study by a team of German, Swiss and American researchers found glycaemic control was improved more than would be predicted by weight loss alone, in type 2 diabetes patients with a body mass index between 27 and 43 kg/m2.

Of the 2,550 patients randomised to either orlistat 120mg or placebo for six or 12 months, those on orlistat had significantly larger reductions in HbA1c (0.74% compared to 0.31% in placebo).

Diabetes, Obesity and Metabolism 2009, 22 January early online publication

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