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Paper of the day - aspirin fails to cut VTE risk

Long-term low-dose aspirin use does not seem to reduce the risk of venous thromboembolism, latest results from the Women's Health Study suggest.

A total of 39,876 healthy US women aged over 45 were randomised to receive aspirin or vitamin E every other day over an average of 10 years' follow-up.

VTE events occurred in 482. Although women taking aspirin were slightly less likely to have a VTE event, the difference was small and not statistically significant, for either provoked or unprovoked events. Researchers concluded that aspirin had no beneficial effects on participants' risk of VTE including a subgroup of women with genetic mutations associated with VTE.

Annals of Internal Medicine 2007;147:525-33

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