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Paper of the day - Bupropion helps quitters

Bupropion helps adolescent smokers quit, but is not as effective as it is in adults, a US drug trial shows.

A total of 312 adolescents aged 14 to 17 years, who smoked at least six cigarettes a day and had tried to quit at least twice, were recruited. For six weeks, a third were given sustained-release bupropion hydrochloride 150mg/day, a third 300mg/day and a third a placebo.

Fewer adolescents taking the 300mg bupropion dose smoked during treatment than those on placebo, except on week four, and at 26 weeks 13.9% were still not smoking. But abstinence rates were lower than in adults, with rapid relapse after the drug was stopped.

Archives of Pediatric and Adolescent Medicine 2007;161:1068-74

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