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Paper of the Day - Combination of BP drugs cuts death risk in diabetes

Giving a fixed dose combination antihypertensive to everyone with Type 2 diabetes- regardless of blood pressure- cuts the risk of cardiovascular death by 18% according to a study of over 110,000 patients.

Patients with a range of blood pressures at baseline were randomised to receive a fixed dose of the ACE inhibitor perindopril and the thiazide diuretic indapamide or placebo.

After an average 4.3 years follow up, blood pressures in the intervention group were 5.6/2.2 mmHg lower than the placebo arm.

The relative risk of death from cardiovascular disease in the intervention group was reduced by 18% and death from any cause was down by 14%.

Such treatment should be considered routinely for anyone with type 2 diabetes say the authors.

The Lancet online September 2.

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