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Paper of the Day - Lung disease boosts fracture risk

Patients with chronic lung disease such as COPD or emphysema have a small but significant increased risk of fracture of between 19 and 31% according to a Danish case-control study.

The study of 124,655 patients who had a fracture and 373,962 age and gender matched controls, found an increased risk with both low and high doses of inhaled short-acting beta agonists.

As expected there was a dose-related risjk of fracture with oral steroids. There was also a risk for low but not high doses of oral beta agonists, but no apparent risk for inhaled corticosteroids and most other treatments such as inhaled long-acting beta agonists, inhaled anti-muscarinic agents and oral leukotriene receptor agonists.

Chest online September 21

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