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Paper of the day - switch to glargine improves diabetes control

Switching Type 2 diabetes patients poorly controlled on pre-mixed insulins to glargine significantly improves glycaemic control, say UK researchers.

The safety and efficacy of switching from premixed insulin to the insulin analogue was studied in 686 patients with inadequately controlled diabetes. Twenty-four weeks after switching, average HbA1cs had dropped from 9.0 to 8.0 (p<0.001) and fasting blood glucose levels from 9.27 to 5.93 mmol/l (p,0.001). Adding prandial glucose further improved control. The authors say better control was gained with a low risk of severe hypoglycaemic episodes.

Diabetes Res Clin Pract online 5 November

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