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PPIs linked to pneumonia

Initiation of proton pump inhibitors within the past month is linked to an increased risk of community-acquired pneumonia, but long-term use is not, an analysis of the UK general practice research database suggests.

A comparison of 80,066 patients with community-acquired pneumonia and 799,881 controls showed a sixfold increase in risk in patients prescribed PPI therapy within the previous two days, an almost fourfold increase with PPI initiation in the previous week and a threefold increase within the previous fortnight.

But there was no increased risk for community-acquired pneumonia overall and no significant association with longer-term PPI use.

Annals of Internal Medicine 2008;149:391-8

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