This site is intended for health professionals only

At the heart of general practice since 1960

pul jul aug2020 cover 80x101px
Read the latest issue online

Independents' Day

PPIs raise risk of hospital-acquired pneumonia

PPIs increase the risk of hospital-acquired pneumonia by 30%, according to US researchers.

Their study included 63,878 adults admitted to the Beth Israel Deaconess Medical Center in Boston over three years. Fifty-two per cent were given an acid suppressant - either a PPI or a H2-blocker - during their stay and 4.9% of them developed pneumonia compared to 2% of the unexposed patients.

The authors conclude that the use of a PPI significantly increased the risk of pneumonia by 30% but H2-blockers were associated with a non-significant 20% increase risk.

JAMA 2009; 301(20):2120-2128.

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say