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Antidepressant use in pregnancy linked to child psychiatric disorders


My immediate thought was that those mothers with more severe true depression and more clearly needing to continue antidepressants were the ones who did so. However, this was taken into account to some extent. From the study: "The risk for psychiatric disorders among offspring in the continuation group was higher than that in the discontinuation group (hazard ratio 1.27, 95% confidence interval 1.17 to 1.38). This was apparent after adjustment for demographic and psychiatric characteristics of the mothers, including inpatient and outpatient psychiatric treatment and comorbid psychotropic drug use (table 2⇓). The population attributable fraction was 0.5%, indicating that continuous antidepressant use during pregnancy explained 0.5% of psychiatric cases in the study population, assuming an unconfounded causal association." (ONLY 0.5% - my comment) Study conclusion: "Antidepressant use during pregnancy was associated with increased risk of psychiatric disorders in offspring. The association may be attributable to the severity of underlying maternal disorders in combination with antidepressant exposure in utero. Our findings suggest that focusing solely on a single psychiatric disorder among offspring in studies of in utero antidepressant exposure may be too restrictive." Perhaps the headline ought to be "Mothers with depression, especially if severe, more likely to have children with psychiatric disorders." That would however not be so interesting.

Posted date

07 Sep 2017

Posted time