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SSRIs raise gastrointestinal bleed risk, says study

Use of SSRIs is associated with a 30% increased risk of gastrointestinal bleed, analysis of UK data shows.

In particular, venlafaxine was found to be associated with a 90% increased risk of GI bleeding.No such link was found in patients taking tricyclic antidepressants, the study published in the British Journal of Clinical Pharmacology (6th May 2008) showed.

The study of more than 4000 cases of GI bleed and 40,000 controls taken from the general practice research database found no drug interaction between warfarin anticoagulation and antidepressant use.

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