Statins 'best with CCBs'
Statins may be much more effective when prescribed with some antihypertensive drugs than with others.
Results emerging from the ASCOT trial suggest calcium channel blockers may work synergistically with statin treatment to cut cardiovascular risk.
The findings, published online by the European Heart Journal, showed statins reduced risk of coronary heart disease by 53 per cent in those on amlodipine, compared with 16 per cent in those on ß-blocker atenolol.
Study leader Professor Peter Sever, professor of clinical pharmacology and therapeutics at Imperial College London, said the discovery warranted independent evaluation and was not just a chance finding. 'The benefits appear three times greater if you are on a calcium-based treatment plus a statin, versus a ß-blocker plus a statin,' he said.
In the continuing trial, 19,257 hypertensive patients were randomised to either
amlodipine or atenolol, with 10,305 also prescribed atorvastatin or placebo.