Strict BP control 'reduces left ventricular hypertrophy'
Treating non-diabetic patients to a blood pressure target of <130mm Hg is associated with a reduction in left ventricular hypertrophy (LVH), according to Italian researchers.
They randomised 967 non-diabetic patients with hypertension and an average age of 67 to be treated to a ‘tight' systolic blood pressure target below 130 mm Hg or a ‘usual' target below 140 mm Hg. After a median follow-up of two years, systolic and diastolic blood pressure were reduced by a mean of 3.8/1.5 mmHg more in the tight control group.
But LVH occurred in significantly fewer patients in the tight control group, at 11.4%, than the 17% seen in the usual in the usual-control group. Side effect were rare and did not differ significantly between the two groups, the researchers noted.
Lancet 2009; 374: 525–33