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At the heart of general practice since 1960

THE ASCOT AFTERMATH - What GPs Need to Know

Dr Mukul Agarwal helped guide 11 disabled people through the dense jungle of Nicaragua for the BBC2 series Beyond Boundaries.

Dr Agarwal, a GP in Bromley, said the experience was challenging, to say the least.

His toughest decision came when one of the participants, an amputee, discovered a lump on his stump that had a high chance of being cancerous.

Dr Agarwal said: ‘He was desperate to stay but psychologically he was in no state to continue. When he decided to leave I had a little cry.

‘Nobody got killed and nobody came back irreversibly damaged, so my goals were achieved.'

Timeline

Are the days numbered for use of B-blockers in hypertension?
2004
December - Bllod pressure arm of ASCOT trial stopped a year early after finding an ACE inhibitor plus calcium channel blocker had 'substantial benefits' over a B-blocker and diuretic
December - Life trial of more than 9,000 patients found risk of dying from stroke was 35% lower with ARB than a B-blocker
2005
March - More results from the ASCOT trial are unveiled at the American College of Cardiology meeting in Orlando showing that an ACE inhibitor and calcium channel blocker could cut all-cause mortality by 15% compared with a diuretic and B-blocker; NICE and BHS announce they are to hold a high level meeting to issue new guidance when results are published.
September
Formal release of ASCOT data prompts NICE to announce it will review its guidance in the light of the data.

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