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Tiotropium best at cutting COPD exacerbations

Tiotropium reduces the risk of exacerbations and hospitalisations compared with combined ipratropium/salbutamol in patients with COPD, a UK study concludes.

The researchers analysed data on 4,193 patients on the UK general practice research database, 3,385 of them on tiotropium and 808 of them on ipratropium/salbutamol.

After controlling for the severity of illness, treatment with tiotropium reduced the risk of an exacerbation by 26% and the risk of COPD-related referrals and hospitalisations by 43%.

Primary Care Respiratory Journal 2008 2 April early online publication

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