Warning on NSAID use in heart failure
Cardiovascular experts have warned GPs to avoid NSAIDs in patients with heart failure after a study of UK general practice found they increased the risk of hospitalisation with the disease.
Researchers found NSAIDs increased the risk of a first hospitalisation with heart failure by 30 per cent a risk they said, although small, 'could have a considerable public health impact'.
Patients with a prior diagnosis of heart failure were at a 7.3-fold increased risk of a hospitalisation compared with those without the disease, and this rose to a 8.6-fold increase in patients on NSAIDs.
Study leader Dr Consuelo Huerta, a researcher at the Spanish Centre for Pharmaco-epidemiologic Research in Madrid, said: 'NSAIDs should be used with caution by patients at high risk of hospital admission due to heart failure such as those with prior clinical HF, diabetes, renal failure or treatment with hypertension drugs.'
Dr Gerald Partridge, CHD lead at Airedale and North Bradford PCTs and a GP in Keighley, West Yorkshire, said: 'It makes every kind of sense to avoid
giving a heart failure patient
a drug that adversely affects
the neuro-hormonal milieu of the body as NSAIDs probably do via adverse effects on the
The study, published online by Heart and previously reported by Pulse, analysed data on more than 6,000 patients from the UK general practice research database.