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Women are more susceptible than men to developing lung cancer

A study of lung cancer susceptibility and survival has found that women smokers are almost twice as susceptible to tobacco carcinogens than men, but have a lower rate of fatal outcome from lung cancer.

The researchers used prospective collection of data based on baseline–computed tomographic screening lung cancer and follow-up of diagnosed lung cancer in the US between 1993 and 2005. A total of 9427 men and 7498 women were screened all of whom were asymptomatic, aged at least 40 years and had a history of cigarette smoking.

Lung cancer was diagnosed in 113 men and 156 women with the prevalence odds ratio when comparing women with men was 1.9. While the hazard ratio of fatal outcome of lung cancer of 0.48 showed that women were more likely to survive the disease.

Reference

International Early Lung Cancer Action Program Investigators. Women's susceptibility to tobacco carcinogens and survival after diagnosis to lung cancer. JAMA 2006:296;180–4

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