Cookie policy notice

By continuing to use this site you agree to our cookies policy below:
Since 26 May 2011, the law now states that cookies on websites can ony be used with your specific consent. Cookies allow us to ensure that you enjoy the best browsing experience.

This site is intended for health professionals only

At the heart of general practice since 1960

PPI-clopidogrel combination 'does not raise CVD event risk'

By Christian Duffin

A large observational study has found that concurrent use of a proton-pump inhibitor with clopidogrel after acute myocardial infarction is not associated with an increased risk of cardiovascular mortality or death.

Previous research has suggested that patients who are prescribed the two drugs together whilst hospitalised for a heart attack of are at increased risk of a subsequent cardiovascular event.

French researchers examined the FAST-MI registry, a database of 3670 patients presenting with definite myocardial infarction. Patients were categorised according to use of clopidogrel and/or PPI within 48 hours after hospital admission.

PPI use was not associated with an increased risk of another infarction, stroke, bleeding or transfusion whilst in hospital. PPI treatment was not an independent predictor of one-year survival or one-year myocardial infarction, stroke, or death.

Dr Simon Tabbassome, a pharmacologist in the clinical research unit at Université Pierre et Marie Curie in Paris, concluded: ‘PPI use was not associated with an increased risk of cardiovascular events or mortality in patients administered clopidogrel for recent MI.'

Circulation, online 24 January 2011

PPI and clopidogrel use does not worsen outcomes after a year

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say