Cookie policy notice

By continuing to use this site you agree to our cookies policy below:
Since 26 May 2011, the law now states that cookies on websites can ony be used with your specific consent. Cookies allow us to ensure that you enjoy the best browsing experience.

This site is intended for health professionals only

At the heart of general practice since 1960

Statins ‘have no effect’ on mortality in women

Statins have no significant effect on all-cause mortality and the risk of recurrent stroke in women with cardiovascular disease, concludes a meta-analysis.

The researchers pooled 11 secondary prevention trials with statins that had a minimum follow-up of 16 weeks and involved 43,191 patients with pre-existing cardiovascular disease.

They found that statin treatment significantly reduced the risk of all-cause mortality in men by 21% compared to those on placebo, but in women the reduction was only 8% and was non-significant.

A similar disparity was also found in stroke recurrence risk – significantly reduced in men by 18% compared with placebo, but a non-significant decrease with statin treatment of 8% in women.

Reductions in myocardial infarction risk and prevention of any cardiovascular event were similar between genders.

The researchers from Columbia University, USA, concluded: ‘Increased awareness of this disparity is needed, and public policies addressing sex-specific differences in cardiovascular health are encouraged.'

Arch Intern Med 2012, online 25 June

Rate this article  (4 average user rating)

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say