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Omicron infection less likely to trigger long Covid than Delta, finds large study

Omicron infection less likely to trigger long Covid than Delta, finds large study

Patients are less likely to develop long Covid with the currently dominant strain of the virus, according to a large study.

Analysing data from the ZOE symptoms study app, researchers concluded that 10.8% of patients who tested positive for Covid while Delta was the dominant strain reported long Covid symptoms.

However, since the Omicron strain took over as the most prevalent in the UK, just 4.5% of Covid-positive study participants developed long Covid.

The paper, published in the Lancet, said: ‘Overall, we found a reduction in odds of long Covid with the omicron variant versus the delta variant of 0.24-0.50 depending on age and time since vaccination.’

However, despite the decreasing risk, the King’s College London researchers predicted that more people are going to come forward with long Covid.

The paper said: ‘Considering the UK omicron peak of more than 350,000 new symptomatic Covid-19 cases per day estimated on March 26, 2022, by the ZOE app model and 4% of cases being long Covid, future numbers with long Covid will inevitably rise.’

Methodology and results

Research cohort:

Omicron group: 56,003 UK adults first testing positive between Dec 20, 2021, and March 9, 2022, when more than 70% of UK cases were estimated to be attributable to the omicron variant.

Delta group: 41 361 UK adult cases first testing positive between June 1, 2021, and Nov 27, 2021, when more than 70% of cases were attributable to the delta variant.

Both symptomatic and asymptomatic infections were considered.


Among omicron cases, 2,501 (4.5%) experienced long Covid and, among delta cases, 4,469 (10.8%) experienced long Covid.

Omicron cases were less likely to experience long Covid for all vaccine timings, with an odds ratio ranging from 0.24 (0.20-0.32) to 0.50 (0.43-0.59). These results were also confirmed when the analysis was stratified by age group.

Source: Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2, published in the Lancet

Dr David Strain, clinical senior lecturer and honorary consultant at the University of Exeter Medical School, welcomed the study but said it was ‘important to say however that these data come from the omicron BA.1 period’. 

‘The Office for National Statistics suggested that the BA.2 variant that has caused much of the recent wave, did cause long Covid in triple-vaccinated people at approximately the same rate as the Delta.

‘Obviously, it is impossible to comment on the longer term impact of these variants as we are still in the early days. If the resolution rate for these people with omicron BA.1 remains at 50% between week 4 and week 12, and a further 12.5% for those who still have symptoms at 12 weeks, this will be very good news for all the healthcare services that are concerned about the potential number of long Covid patients over the next 2-3 years.

‘It is feasible, however, that those who got long Covid despite triple vaccination and the more mild BA.1 omicron variant are in some way more susceptible and may not follow the same course.’

And he said that ‘even 4.4% of the very large number who experienced Covid as protections were eased, creates a significant public health burden of this disease with no known treatment, or even reliable diagnostic test’.

Last month, a study suggested that vaccination of patients who already have long Covid may help lessen their symptoms.

Another study of UK data had shown that being fully vaccinated against coronavirus before infection cut the risk of long Covid in half.

GPs are still awaiting a plan to ‘further clarify the role of general practice’ in supporting patients with long Covid, which a health minister had promised was due in the spring.

NICE published its final guideline on long Covid in November last year, which said GPs should consider referring patients with long-term symptoms of Covid-19 to specialist clinics as soon as four weeks after acute infection after ruling out other diagnoses.

Last year, NHS England announced that GPs would be funded to treat patients suffering with long Covid via a new enhanced service worth £30m.

At least 93% of GP practices signed up to deliver the long Covid enhanced service.


Visit Pulse Reference for details on 140 symptoms, including easily searchable symptoms and categories, offering you a free platform to check symptoms and receive potential diagnoses during consultations.


Please note, only GPs are permitted to add comments to articles

Dave Haddock 17 June, 2022 6:15 pm

Perhaps “Long Covid” has very little to do with Covid infection, and more to do with the mass hysteria that was the response? Endless experts telling us we were all going to die, daily accounts of the latest death toll, isolated by lockdowns from normal support networks, people wandering about in biological warfare kit; enough to give anyone a nervous breakdown.
By the time more recent strains emerged the hysteria had eased as it became more obvious that most people didn’t actually die, and the anxiety diminished.

Patrufini Duffy 20 June, 2022 2:39 pm

You know what they don’t tell you.
Who actually attends the long covid clinics. That’ll tell you a lot about the “system”. It’s not who you think should be attending.