This site is intended for health professionals only


Renin inhibitors cause fewer side effects



By Christian Duffin

Hypertension patients experience less peripheral oedema as a side-effect when taking renin inhibitors as part of combination therapy than calcium channel inhibitors, a US study has shown.

Researchers analysed 25 randomised controlled trails comparing calcium channel blocker monotherapy with combination calcium channel blocker and renin inhibitor therapy in patients with hypertension.

The incidence of peripheral oedema seen with combination therapy was 38% lower than with monotherapy among the 17,206 patients involved, whose average age was 56.

The risk of withdrawal due to peripheral oedema was 62% lower for combination therapy compared to monotherapy.

Lead researcher Dr Harikrishna Makani, a post-doctoral clinical fellow at Columbia University, New York, said: ‘In patients with hypertension, the calcium channel blocker/renin-angiotensin system blocker combination reduces the risk of calcium channel blocker-associated peripheral oedema when compared with calcium channel blocker monotherapy.’

American Journal of Hypertension 2011 vol 124, issue 2, pp 128-35

Renin causes less peripheral oedema in patients with hypertension