This site is intended for health professionals only


Multivitamins ‘do not reduce major cardiovascular events’



Multivitamin supplements do not reduce the risk of major cardiovascular events in men and should only be taken if a patient’s nutritional status warrants it, say US researchers.

The 13-year study into 14,461 men aged over 50 years, randomised to receive either a multivitamin or placebo, found a non-significant difference of 1% between the two groups in the risk of major cardiovascular events.

Patients were excluded if they reported taking anticoagulants or a history of liver cirrhosis.

There was also no difference in the risk of myocardial infarction, with only a non-significant 7% decrease in risk for those taking multivitamin compared to men on placebo.

The difference in total stroke risk between the multivitamin group, compared with the placebo group, was also non-significant between the two groups, despite a 6% increase in risk for participants taking multivitamins.

The authors concluded: ‘These data do not support multivitamin use to prevent cardiovascular disease. Whether to take a daily multivitamin mmummrequires consideration of an individual’s nutritional status.’

JAMA 2012, available online 5 November